Open AccessAn EBV+ lymphoepithelioma-like cholangiocarcinoma in a young woman with chronic hepatitis B
Author(s) -
Sofia V Gearty,
Ayman Al Jurdi,
Meredith E. Pittman,
Richa Gupta
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2019-229520
Subject(s) - medicine , chronic hepatitis , lymphoepithelioma , epstein–barr virus , lymphoepithelioma like carcinoma , pathology , dermatology , general surgery , gastroenterology , virus , virology
Epstein-Barr virus (EBV) is implicated in the tumorigenesis of a variety of malignancies, including Burkitt's lymphoma, Hodgkin's disease and nasopharyngeal carcinoma (NPC). EBV+ lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare type of intrahepatic cholangiocarcinoma with a distinct pathology and poorly understood treatment options. Morphologically, this neoplasm resembles undifferentiated NPC, a commonly EBV+ tumour with a prominent lymphoid infiltrate. Almost all of the current literature regarding LELCC describes early stage tumours that are treated surgically and achieve good outcomes. In contrast, this report documents a late stage LELCC treated unsuccessfully with systemic chemotherapy.