Open AccessProton beam therapy for malignant transformation of intracranial epidermoid cyst
Author(s) -
Zhe Chen,
Masayuki Araya,
Hiroshi Oda
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2019-229388
Subject(s) - medicine , hypesthesia , radiation therapy , paresis , epidermoid cyst , hypoalgesia , radiology , proton therapy , trigeminal nerve , surgery , receptor , hyperalgesia , nociception
We report the first clinical case on the successful use of proton beam therapy in the management of malignant transformation of intracranial epidermoid cyst. A 43-year-old man was initially diagnosed as this disease with left facial paresis, hypesthesia and hypoalgesia in the territories of the trigeminal nerve. After failure of surgical interventions, he was referred to our radiation centre. We performed a postoperative proton beam therapy for treatment. We delivered a total dose of 57 GyE in 31 fractions. He tolerated the treatment well with mild acute toxicities and remained healthy and functional by 2-year follow-up postradiotherapy. No evidence of delayed radiation-induced neurotoxicity was observed.