Open AccessSuccessful clozapine rechallenge in a patient with suspected drug induced lupus
Author(s) -
Suraj Pathak,
Scott Cherry,
Samreen Samad,
Ambreen Aftab
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-228574
Subject(s) - clozapine , medicine , drug , systemic lupus erythematosus , schizophrenia (object oriented programming) , refractory (planetary science) , intensive care medicine , pharmacology , psychiatry , disease , physics , astrobiology
Clozapine is the most effective treatment for patients with refractory schizophrenia. Clozapine is also associated with serious and potentially lethal side effects including drug induced lupus (DIL). There have been four previous published case reports describing clozapine inducing a lupus-like syndrome including one previous case where a clozapine rechallenge was attempted without success. This case report describes a successful clozapine rechallenge in a patient with suspected DIL.