Open AccessRetrograde ejaculation associated with quetiapine and treatment with low-dose imipramine
Author(s) -
Matthew Roughley,
Marc Lyall
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-228539
Subject(s) - quetiapine , thioridazine , medicine , risperidone , imipramine , antipsychotic , atypical antipsychotic , clozapine , psychosis , psychiatry , antipsychotic agent , quetiapine fumarate , pharmacology , schizophrenia (object oriented programming) , chlorpromazine , alternative medicine , pathology
Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.