Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine | Zendy

Matthew Roughley | Zendy; Marc Lyall | Zendy

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Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine

Author(s) -

Matthew Roughley,

Marc Lyall

Publication year - 2019

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr-2018-228539

Subject(s) - quetiapine , thioridazine , risperidone , antipsychotic , imipramine , clozapine , atypical antipsychotic , psychosis , medicine , psychiatry , quetiapine fumarate , antipsychotic agent , pharmacology , psychology , schizophrenia (object oriented programming) , chlorpromazine , alternative medicine , pathology

Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.

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