Open AccessXanthoma disseminatum with neurological involvement and optic atrophy: improvement with cladribine
Author(s) -
Suman Patra,
Saurabh Bhatia,
Binod K. Khaitan,
Neetu Bhari
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-228464
Subject(s) - medicine , cladribine , diabetes insipidus , atrophy , polyuria , pathology , histiocytosis , histopathology , neurology , polydipsia , dermatology , diabetes mellitus , disease , psychiatry , endocrinology
A 9-year-old boy presented with multiple hyperpigmented papules over flexors with polyuria, polydipsia and progressive loss of vision. Histopathology of papule suggested a diagnosis of non-Langerhans cell histiocytosis and systemic evaluation showed central diabetes insipidus and optic atrophy. With a diagnosis of xanthoma disseminatum with significant neurological involvement, he received cladribine therapy and showed significant improvement in both cutaneous and nervous system lesions.