Open AccessCone Beam CT study of a case of eosinophilic granuloma of the mandible in a young patient
Author(s) -
Rossana Izzetti,
Emanuela De Marco,
Davide Caramella
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-228455
Subject(s) - medicine , eosinophilic granuloma , langerhans cell histiocytosis , differential diagnosis , histiocyte , rare disease , mandible (arthropod mouthpart) , pathological , biopsy , lesion , eosinophilic , pathology , histiocytosis , disease , radiology , botany , biology , genus
Eosinophilic granuloma (EG) is a rare bony disease deriving from abnormal proliferation of histiocytes, and is the most common form of presentation of Langerhans cell histiocytosis. EG predominantly affects the axial skeleton. However, when localised in the head and neck district, mandibular lesions account for the majority of cases. Mandibular lesions can mimic other pathological conditions, making biopsy fundamental for differential diagnosis. Treatment depends on the severity of the disease, ranging from pharmacological treatment to surgical approach. However, EG is also reported to possibly undergo spontaneous resolution. In this case report, we describe a rare case of EG with particularly aggressive behaviour in a young patient. Initially, local pharmacological treatment with intralesional administration of corticosteroids lead to worsening of the symptoms, increase in lesion's dimensions, and disruption of the cortical bone. A more invasive therapeutic approach involving radical surgery was then performed, with consequent resolution of the disease.