Open AccessChronic meningoencephalitis with mixed pathology mimics progressive supranuclear palsy
Author(s) -
Marian L. Dale,
Deniz Erten-Lyons,
Frank Bittner,
Randy Woltjer
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-227119
Subject(s) - progressive supranuclear palsy , pathology , medicine , tauopathy , meningoencephalitis , pathological , cerebrospinal fluid , dementia , central nervous system , white matter , neurology , disease , magnetic resonance imaging , radiology , neurodegeneration , psychiatry
We report a case of a progressive supranuclear palsy-like phenotype with rapidly progressive dementia and prominent language and executive dysfunction. Pathological examination revealed no midbrain or white matter tauopathy, but rather chronic meningoencephalitis and other mixed pathology. The cerebrospinal fluid (CSF) in this case showed a novel antibody against central nervous system and renal tissue.