Recurrent abducens nerve palsy and hypophosphatasia syndrome | Zendy

Neha Khade | Zendy; Simon Carrivick | Zendy; Carolyn Orr | Zendy; David Prentice | Zendy

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Recurrent abducens nerve palsy and hypophosphatasia syndrome

Author(s) -

Neha Khade,

Simon Carrivick,

Carolyn Orr,

David Prentice

Publication year - 2019

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr-2018-226895

Subject(s) - hypophosphatasia , calcification , medicine , abducens nerve , skull , anatomy , palsy , surgery , alkaline phosphatase , radiology , pathology , biology , biochemistry , alternative medicine , enzyme

A 47-year-old woman presented with six episodes of horizontal binocular double vision over a 2-year period. CT imaging was significant for extensive dural calcification in the spine and calcification of the skull base, likely involving Dorello's canal. Biochemical testing revealed a persistently low alkaline phosphatase level. Recurrent nerve palsy may possibly be induced by mechanical compression of the sixth cranial nerve in Dorello's canal from calcification due to hypophosphatasia syndrome.

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