Open AccessRecurrent abducens nerve palsy and hypophosphatasia syndrome
Author(s) -
Neha Khade,
Simon Carrivick,
Carolyn Orr,
David Prentice
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-226895
Subject(s) - hypophosphatasia , medicine , calcification , abducens nerve , skull , palsy , surgery , anatomy , alkaline phosphatase , radiology , pathology , biochemistry , chemistry , alternative medicine , enzyme
A 47-year-old woman presented with six episodes of horizontal binocular double vision over a 2-year period. CT imaging was significant for extensive dural calcification in the spine and calcification of the skull base, likely involving Dorello's canal. Biochemical testing revealed a persistently low alkaline phosphatase level. Recurrent nerve palsy may possibly be induced by mechanical compression of the sixth cranial nerve in Dorello's canal from calcification due to hypophosphatasia syndrome.