Open AccessAnti-HMGCR antibody-associated necrotising myopathy and its association with statin use
Author(s) -
Ylenia Abdilla,
Charmaine Chircop,
Norbert Vella
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-226302
Subject(s) - medicine , myopathy , muscle biopsy , creatine kinase , weakness , statin , atrophy , muscle atrophy , inflammatory myopathy , myalgia , muscle weakness , gastroenterology , biopsy , pathology , surgery
A 66-year-old man presented with chest pain and a 1-year history of generalised weakness, accompanied with generalised aches and pains. Symptoms worsened when he was initiated on statins. Investigations yielded high creatine kinase, high HMG-coenzymeA reductase (HMGCR) antibody titre, myopathic features on electromyography and muscle biopsy, and muscle atrophy on MRI. These results were in keeping with anti-HMGCR antibody myopathy. The patient responded well to immunosuppressive therapy.