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Interstitial lung disease and inflammatory myopathy in antisynthetase syndrome with PL-12 antibody
Author(s) -
Ameen Jubber,
Mudita Tripathi,
James R. Taylor
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-226119
Subject(s) - antisynthetase syndrome , medicine , interstitial lung disease , inflammatory myopathy , prednisolone , dysphagia , myopathy , cyclophosphamide , dermatomyositis , proximal muscle weakness , gastroenterology , azathioprine , dermatology , pathology , disease , lung , surgery , chemotherapy , muscle biopsy , biopsy
We report the case of an 80-year-old Caucasian man with PL-12 antibody positive antisynthetase syndrome. He presented with progressive dyspnoea and weight loss, later developing dysphagia, mild proximal muscle weakness and mild sicca symptoms. Investigations revealed interstitial lung disease, inflammatory myopathy and an immunology profile consistent with PL-12 antisynthetase syndrome. Prednisolone and cyclophosphamide resulted in a significant improvement of all his symptoms.

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