Open AccessThrombocytopenia-associated multiple-organ failure (TAMOF): recognition and management
Author(s) -
Musaab Ramsi,
Alyaa Saeed Al Ali
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-225594
Subject(s) - medicine , thrombospondin , sepsis , metalloproteinase , immune dysregulation , disintegrin , severe sepsis , organ dysfunction , immune system , bioinformatics , immunology , intensive care medicine , septic shock , matrix metalloproteinase , biology
Thrombocytopenia-associated multiple-organ failure (TAMOF) is an increasingly fatal phenomenon that may be associated with sepsis. TAMOF results from immune dysregulation and impaired activity of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13. Early recognition of this premorbid condition and specific management results in a significantly improved outcome. Herein, we report the presentation and management of a 2-year-old child with TAMOF who was successfully treated with plasma exchange and recovered without long-term sequelae.