Open AccessAcquired generalised lipodystrophy and type 1 diabetes mellitus in a child: a rare and implacable association
Author(s) -
Rakesh Kumar,
Rakesh Kumar Pilania,
Anmol Bhatia,
Devi Dayal
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-225553
Subject(s) - medicine , pioglitazone , lipodystrophy , diabetes mellitus , type 1 diabetes , insulin resistance , metformin , type 2 diabetes mellitus , type 2 diabetes , pediatrics , insulin , endocrinology , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
Lipodystrophy syndromes are frequently associated with marked degree of insulin resistance and lipoatrophic diabetes. Although acquired generalised lipodystrophy (AGL) has been known to be associated with various autoimmune disorders, type 1 diabetes mellitus (T1DM) is very rarely reported to occur with AGL. Combination of AGL and T1DM can lead to a totally different phenotype with very difficult-to-treat diabetes and progressive complications of both the conditions. We report a case of AGL with T1DM with poor diabetes control despite high doses of insulin, metformin and pioglitazone. Our case further progressed to develop complication of retroperitoneal fibrosis, not hitherto reported with AGL.