Open AccessDelayed Presentation of Isolated Adrenocorticotropin Insufficiency after Nivolumab Therapy for Advanced Non-small-cell lung carcinoma (NSCLC)
Author(s) -
Shiva Shrotriya,
P Manoj,
Ahmad Alratroot,
Erin M. Sarzynski
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2018-225048
Subject(s) - medicine , nivolumab , malaise , adrenal insufficiency , lung , presentation (obstetrics) , weight loss , lung cancer , carcinoma , oncology , etiology , cancer , gastroenterology , surgery , immunotherapy , obesity
We describe a 73-year-old man who developed adrenal insufficiency 7 months after completing nivolumab therapy for advanced non-small cell lung cancer. He presented with non-specific symptoms of malaise and fatigue with an insidious 13.6 kilogram weight loss, prompting an evaluation for disease progression, which was negative. Subsequent evaluation revealed isolated adrenocorticotropin insufficiency as the aetiology, attributed to a delayed side effect of nivolumab therapy.