Hydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo | Zendy

Leo Reap | Zendy; Cassandra Rodd | Zendy; José M. Larios | Zendy; Michael Marshall | Zendy

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Hydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo

Author(s) -

Leo Reap,

Cassandra Rodd,

José M. Larios,

Michael Marshall

Publication year - 2019

Publication title -

bmj case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.231

H-Index - 26

ISSN - 1757-790X

DOI - 10.1136/bcr-2017-223528

Subject(s) - dermatology , impetigo , hydrochlorothiazide , acute generalized exanthematous pustulosis , medicine , terbinafine , adverse effect , pharmacology , antifungal , itraconazole , blood pressure

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction characterised by the appearance of erythematous plaques and papules with overlying non-follicular pinpoint pustules. Drugs are the cause of AGEP in approximately 90% of cases. The most common causes include anti-infective agents (aminopenicillins, quinolones, antibacterial sulfonamides and terbinafine), antimalarials and diltiazem. To the best of our knowledge, to date there has only been one report of hydrochlorothiazide-induced AGEP. There has never been a case report of losartan-induced AGEP. Here, we present a case of AGEP that is the second case purportedly caused by hydrochlorothiazide.

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