Open AccessHydrochlorothizide-induced acute generalised exanthematous pustulosis presenting with bilateral periorbital impetigo
Author(s) -
Leo Reap,
Cassandra Rodd,
José M. Larios,
Michael Marshall
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2017-223528
Subject(s) - medicine , acute generalized exanthematous pustulosis , dermatology , impetigo , hydrochlorothiazide , terbinafine , antifungal , itraconazole , blood pressure
Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction characterised by the appearance of erythematous plaques and papules with overlying non-follicular pinpoint pustules. Drugs are the cause of AGEP in approximately 90% of cases. The most common causes include anti-infective agents (aminopenicillins, quinolones, antibacterial sulfonamides and terbinafine), antimalarials and diltiazem. To the best of our knowledge, to date there has only been one report of hydrochlorothiazide-induced AGEP. There has never been a case report of losartan-induced AGEP. Here, we present a case of AGEP that is the second case purportedly caused by hydrochlorothiazide.