Open AccessRare case of triple mutant (KRAS + NRAS + BRAF) metastatic colon adenocarcinoma
Author(s) -
Anusha Vittal,
Disha Sharma,
Ipsita Samanta,
Anup Kasi
Publication year - 2019
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2017-221816
Subject(s) - kras , medicine , neuroblastoma ras viral oncogene homolog , colorectal cancer , adenocarcinoma , concomitant , oncology , cancer
KRAS is detected in 30%-50% of colorectal cancer (CRC) and BRAF mutations are found in 10% of CRC. A 62-year-old man with the long-standing smoking history presented to the emergency department with abdominal pain, weight loss and constipation. CT scan of abdomen/pelvis showed obstructive mass which was found to be colon adenocarcinoma which on further molecular analysis tested positive for KRAS, NRAS and BRAF mutations. His tumour progressed despite chemotherapy and surgery and he died within a year of diagnosis. Concomitant KRAS, NRAS and BRAF mutations are rare enough to be considered mutually exclusive but coexistent mutations appear to be a distinct molecular and clinical subset which needs new and effective treatment strategies in a setting of dismal prognosis.