Open AccessMöbius syndrome associated with obesity and precocious puberty
Author(s) -
Samantha De Silva,
Sally Painter,
Darius Hildebrand
Publication year - 2018
Publication title -
bmj case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 26
ISSN - 1757-790X
DOI - 10.1136/bcr-2017-219590
Subject(s) - medicine , precocious puberty , hypogonadotrophic hypogonadism , pediatrics , delayed puberty , neurology , obesity , hypothalamic disease , diabetology , hypogonadotropic hypogonadism , endocrinology , diabetes mellitus , hormone , psychiatry
Möbius syndrome is a neurological disorder involving underdevelopment of the sixth and seventh cranial nerves. Multiple associations have been described including dysfunction of other cranial nerves, limb abnormalities and hypogonadotrophic hypogonadism causing delayed puberty. We present the second reported case of Möbius syndrome associated with obesity and with precocious puberty. These features may be secondary to dysregulation of the hypothalamic-pituitary axis. We highlight the need to consider extraocular symptoms in these patients and for close liaison with physicians in their management.