Open AccessHypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature
Author(s) -
Patrick Coit,
Xiavan Roopnarinesingh,
Lourdes Ortiz-Fernández,
Kathleen McKin-Maksimowicz,
Emily Lewis,
Joan T. Merrill,
W. Joseph McCune,
Jonathan D. Wren,
Amr H. Sawalha
Publication year - 2022
Publication title -
annals of the rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.333
H-Index - 240
eISSN - 1468-2060
pISSN - 0003-4967
DOI - 10.1136/annrheumdis-2022-222656
Subject(s) - systemic lupus erythematosus , dna methylation , epigenetics , irf7 , methylation , cpg site , biology , lupus erythematosus , genetics , immunology , microbiology and biotechnology , gene , medicine , gene expression , disease , antibody
Lupus T cells demonstrate aberrant DNA methylation patterns dominated by hypomethylation of interferon-regulated genes. The objective of this study was to identify additional lupus-associated DNA methylation changes and determine the genetic contribution to epigenetic changes characteristic of lupus.