Open AccessTfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity
Author(s) -
Zhenhuan Zhao,
Bihua Xu,
Shuang Wang,
Mianjing Zhou,
Yuefang Huang,
Chaohuan Guo,
Mengyuan Li,
Jijun Zhao,
Sun-sang J. Sung,
Felicia Gaskin,
Niansheng Yang,
Shu Man Fu
Publication year - 2022
Publication title -
annals of the rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.333
H-Index - 240
eISSN - 1468-2060
pISSN - 0003-4967
DOI - 10.1136/annrheumdis-2021-221985
Subject(s) - inflammasome , autoimmunity , medicine , germinal center , antibody , immunology , microbiology and biotechnology , inflammation , b cell , biology
NLRP3 inflammasome regulates T cell responses. This study examined the roles of NLRP3 inflammasome activation in the regulation of T follicular helper (Tfh) cells during humoral response to T dependent antigens and in systemic lupus erythematosus (SLE).