Open AccessSystemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study
Author(s) -
Jin Xia,
Songqiang Xie,
Ke-Qi Liu,
Lin Xu,
Pianpian Zhao,
Si-Rui Gai,
Peng-Lin Guan,
Jinqiu Zhao,
Yanping Zhu,
Lam C. Tsoi,
Philip E. Stuart,
Rajan P. Nair,
Han-Qi Yang,
Yuting Liao,
Kaijing Mao,
Mo-Chang Qiu,
Zhimin Ying,
Bin Hu,
Zhihua Yang,
Wenming Bai,
Xiaowei Zhu,
Peikuan Cong,
James T. Elder,
Zhaoming Ye,
Bin Wang,
Hou-Feng Zheng
Publication year - 2020
Publication title -
annals of the rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.333
H-Index - 240
eISSN - 1468-2060
pISSN - 0003-4967
DOI - 10.1136/annrheumdis-2020-217892
Subject(s) - medicine , psoriasis , osteoporosis , psoriatic arthritis , osteopenia , confounding , arthritis , observational study , physical therapy , bone mineral , dermatology
With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement. And 4904 patients with psoriasis and 847 patients with PsA were included in final analysis. Mendelian randomisation (MR) approach was used to evaluate the causal effect between them.