Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis | Zendy

Chuhan Zhang | Zendy; Xiaofen Liu | Zendy; Hailan Wu | Zendy; Yu Wang | Zendy; Yaxin Fan | Zendy; Beining Guo | Zendy; Xingchen Bian | Zendy; Xin Li | Zendy; Jing Zhang | Zendy

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Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis

Author(s) -

Chuhan Zhang,

Xiaofen Liu,

Hailan Wu,

Yu Wang,

Yaxin Fan,

Beining Guo,

Xingchen Bian,

Xin Li,

Jing Zhang

Publication year - 2022

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.502

H-Index - 51

ISSN - 2165-0497

DOI - 10.1128/spectrum.02730-21

Subject(s) - microphthalmia associated transcription factor , polymyxin b , downregulation and upregulation , skin hyperpigmentation , tyrosinase , wnt signaling pathway , protein kinase b , polymyxin , signal transduction , pi3k/akt/mtor pathway , western blot , melanin , biology , chemistry , microbiology and biotechnology , biochemistry , hyperpigmentation , enzyme , antibiotics , gene

Polymyxin B-induced skin hyperpigmentation seriously affects the psychological health and compliance of patients. This study provides a proteomic clue to the mechanism at the cellular level for understanding polymyxin B-induced hyperpigmentation, contributing to a follow-up investigation of the corresponding PI3K/Akt signaling transduction pathway and calcium signaling pathway.

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