Open AccessProteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis
Author(s) -
Chuhan Zhang,
Xiaofen Liu,
Haijiang Wu,
Yu Wang,
Yaxin Fan,
Beining Guo,
Xingchen Bian,
Xin Li,
Jing Zhang
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02730-21
Subject(s) - microphthalmia associated transcription factor , polymyxin b , downregulation and upregulation , skin hyperpigmentation , tyrosinase , wnt signaling pathway , protein kinase b , polymyxin , signal transduction , pi3k/akt/mtor pathway , western blot , melanin , biology , chemistry , microbiology and biotechnology , biochemistry , hyperpigmentation , enzyme , antibiotics , gene
Polymyxin B-induced skin hyperpigmentation seriously affects the psychological health and compliance of patients. This study provides a proteomic clue to the mechanism at the cellular level for understanding polymyxin B-induced hyperpigmentation, contributing to a follow-up investigation of the corresponding PI3K/Akt signaling transduction pathway and calcium signaling pathway.