Open AccessThe cwp66 Gene Affects Cell Adhesion, Stress Tolerance, and Antibiotic Resistance in Clostridioides difficile
Author(s) -
Qingshuai Zhou,
Feng-Qin Rao,
Zhenghong Chen,
Yuanhui Cheng,
Qifang Zhang,
Jie Zhang,
Zhizhong Guan,
Yan He,
Wenfeng Yu,
Guizhong Cui,
Xiaolan Qi,
Wei Hong
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02704-21
Subject(s) - mutant , biology , microbiology and biotechnology , gene , biochemistry
The cell wall protein 66 gene (cwp66 ) encodes a cell wall protein, which is the second major cell surface antigen ofC. difficile . Although immunological approaches, such as antibodies and purified recombinant proteins, have been implemented to study the role of Cwp66 in cell adhesion, no deletion mutant of thecwp66 gene has yet been characterized.