Development of Early-Life Gastrointestinal Microbiota in the Presence of Antibiotics Alters the Severity of Acute DSS-Induced Colitis in Mice | Zendy

Xiaojun Li | Zendy; Yu Ren | Zendy; Jie Zhang | Zendy; Chunhui Ouyang | Zendy; Chunlian Wang | Zendy; Fanggen Lu | Zendy; Yani Yin | Zendy

Open Access

Development of Early-Life Gastrointestinal Microbiota in the Presence of Antibiotics Alters the Severity of Acute DSS-Induced Colitis in Mice

Author(s) -

Xiaojun Li,

Yu Ren,

Jie Zhang,

Chunhui Ouyang,

Chunlian Wang,

Fanggen Lu,

Yani Yin

Publication year - 2022

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.502

H-Index - 51

ISSN - 2165-0497

DOI - 10.1128/spectrum.02692-21

Subject(s) - gut flora , colitis , biology , gastrointestinal tract , antibiotics , lactation , dysbiosis , microbiology and biotechnology , immunology , physiology , pregnancy , genetics , biochemistry

This study investigated resident microbiota in the whole gastrointestinal (GI) tract to explore gut microbiota development in early life and found that early-life antibiotic exposure exacerbated alterations in gut microbiota and murine dextran sulfate sodium (DSS)-induced colitis. Furthermore, the presence of bacteria in the GI tract of mice before birth and the importance of the lactation period in GI microbiota development were confirmed.

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