Open AccessDevelopment of Early-Life Gastrointestinal Microbiota in the Presence of Antibiotics Alters the Severity of Acute DSS-Induced Colitis in Mice
Author(s) -
Xiaojun Li,
Yuchen Ren,
Jie Zhang,
Chunhui Ouyang,
Chunlian Wang,
Fanggen Lu,
Yani Yin
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02692-21
Subject(s) - gut flora , colitis , biology , gastrointestinal tract , antibiotics , lactation , dysbiosis , microbiology and biotechnology , immunology , physiology , pregnancy , genetics , biochemistry
This study investigated resident microbiota in the whole gastrointestinal (GI) tract to explore gut microbiota development in early life and found that early-life antibiotic exposure exacerbated alterations in gut microbiota and murine dextran sulfate sodium (DSS)-induced colitis. Furthermore, the presence of bacteria in the GI tract of mice before birth and the importance of the lactation period in GI microbiota development were confirmed.