Open AccessLimited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein
Author(s) -
Hanora Van Ert,
Dana Bohan,
Kai J. Rogers,
Mohammad Fili,
Roberth Anthony Rojas Chávez,
Enya Qing,
Changze Han,
Spencer Dempewolf,
Guiping Hu,
Nathan Schwery,
Kristina Sevcik,
Natalie Ruggio,
Devlin Boyt,
Michael Pentella,
Tom Gallagher,
J. Brooks Jackson,
Anna E. Merrill,
C. Michael Knudson,
Grant Brown,
Wendy Maury,
Hillel Haim
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02676-21
Subject(s) - antibody , neutralization , polyclonal antibodies , virology , glycoprotein , virus , potency , biology , spike (software development) , coronavirus , immunology , medicine , microbiology and biotechnology , covid-19 , disease , genetics , management , economics , infectious disease (medical specialty) , in vitro
Infection by SARS-CoV-2 elicits antibodies against various domains of the spike protein, including the RBD and NTD of subunit S1 and against subunit S2. The antibody responses of different infected individuals exhibit different efficacies to inactivate (neutralize) the virus.