Open AccessDiscovery and Characterization of an Aberrant Small Form of Glycoprotein I of Herpes Simplex Virus Type I in Cell Culture
Author(s) -
Xixi Gui,
Wuchao Zhang,
Peng Gao,
Yongning Zhang,
Lei Zhou,
Xinna Ge,
Xin Guo,
John W. Wills,
Jun Han,
Hanchun Yang
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02659-21
Subject(s) - biology , herpes simplex virus , glycoprotein , epitope , virology , antibody , transfection , virus , herpesvirus glycoprotein b , microbiology and biotechnology , cell culture , viral quasispecies , mutagenesis , viral entry , gene , mutation , genetics , viral replication , hepatitis c virus
The HSV-1 gI is required for viral cell-to-cell spread within the host, but its behavior during infection has remained poorly defined. Along with the classic 66 kDa product, here we report a previously unrecognized, approximately 23 kDa form of gI.