Open AccessSystemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV
Author(s) -
Ming Qiu,
Shubin Li,
Mengxue Ye,
Jixiang Li,
Zhe Sun,
Xinshuai Li,
Yan Xu,
Yanzhao Xiao,
Chen Li,
Binghui Feng,
Lin Hong,
Wanglong Zheng,
Xiaofang Yu,
Kegong Tian,
Jianzhong Zhu,
Nanhua Chen
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02574-21
Subject(s) - virology , coinfection , vaccination , porcine reproductive and respiratory syndrome virus , antibody , porcine epidemic diarrhea virus , neutralizing antibody , virus , medicine , biology , immunology
Porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV) coinfection occurs commonly and can synergistically reduce feed intake and pig growth. Vaccination is an effective strategy utilized for PED and PRRS control, and systemic homologous neutralizing antibodies (shnAbs) in serum are commonly used for protective efficacy evaluation of PED and PRRS vaccines.