Open AccessLatent Tuberculosis Infection Diagnosis among Household Contacts in a High Tuberculosis-Burden Area: a Comparison between Transcript Signature and Interferon Gamma Release Assay
Author(s) -
Sheetal Kaul,
Vivek Nair,
Shweta Birla,
Shikha Dhawan,
Sumit Rathore,
Vishal Khanna,
Sheelu Lohiya,
Shakir Ali,
Shamim Mannan,
Kirankumar Rade,
Pawan Malhotra,
Dinesh Gupta,
Ashwani Khanna,
Asif Mohmmed
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02445-21
Subject(s) - tuberculosis , latent tuberculosis , interferon gamma , medicine , interferon γ , virology , immunology , interferon gamma release assay , biology , mycobacterium tuberculosis , demography , pathology , cytokine , sociology
The study compares potential of transcript signature and IGRA to diagnose LTBI. It is first of its kind study to screen household contacts (HHCs) in high TB burden area of India. A transcript signature (FCGR1B, GBP1 , &GBP5 ) is identified as potential biomarker for LTBI. These results can lead to development of point-of-care (POC) like device for LTBI screening in a high TB burdened area.