Open AccessTranscriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana
Author(s) -
Karunakaran Kalesh,
Wenbin Wei,
Brian S. Mantilla,
Theodoros I. Roumeliotis,
Jyoti Choudhary,
Paul W. Denny
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02422-21
Subject(s) - interactome , leishmania , transcriptome , proteomics , biology , rna , computational biology , non coding rna , dna microarray , rna binding protein , genetics , gene , gene expression , parasite hosting , world wide web , computer science
Advances in proteomics and mass spectrometry have revealed the mRNA-binding proteins in many eukaryotic organisms, including the protozoan parasitesLeishmania spp., the causative agents of leishmaniasis, a major infectious disease in over 90 tropical and subtropical countries. However, in addition to mRNAs, which constitute only 2 to 5% of the total transcripts, many types of non-coding RNAs participate in crucial biological processes.