Open AccessA Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle
Author(s) -
Tanmoy Mondal,
Gururaj Shivange,
Alaa Habieb,
Jogender TushirSingh
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02364-21
Subject(s) - furin , protease , biology , coronavirus , viral entry , virology , cleavage (geology) , virus , microbiology and biotechnology , biochemistry , enzyme , covid-19 , viral replication , medicine , infectious disease (medical specialty) , paleontology , pathology , fracture (geology) , disease
Since its emergence in December 2019, COVID-19 has remained a global economic and health threat. Although RNA and DNA vector-based vaccines induced antibody response and immunological memory have proven highly effective against hospitalization and mortality, their long-term efficacy remains unknown against continuously evolving SARS-CoV-2 variants.