Open AccessAvian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization
Author(s) -
Beibei Zhang,
Mengnan Fan,
Jie Fan,
Yuhang Luo,
Jie Wang,
Yajing Wang,
Baoyuan Liu,
Yani Sun,
Qin Zhao,
Julian A. Hiscox,
Yuchen Nan
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02265-21
Subject(s) - internalization , microbiology and biotechnology , cytoplasm , cytoskeleton , virus , virology , biology , cell , chemistry , genetics
Rap1b is a multifunctional protein that is responsible for cell adhesion, growth, and differentiation. The inactive form of Rap1b is phosphorylated and distributed in the cytoplasm, while active Rap1b is prenylated and loaded with GTP to the cell membrane.