Open AccessLimited Mechanistic Link Between the Monod Equation and Methanogen Growth: a Perspective from Metabolic Modeling
Author(s) -
Qusheng Jin,
Qiong Wu,
Benjamin M. Shapiro,
Shan E. McKernan
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02259-21
Subject(s) - methanogen , structural equation modeling , link (geometry) , perspective (graphical) , metabolic network , biochemical engineering , biology , econometrics , economics , ecology , computational biology , mathematics , computer science , statistics , engineering , artificial intelligence , methane , combinatorics
The Monod equation has been widely applied to predict the rate of microbial growth, but its application is not always successful. Using a novel metabolic modeling approach, we simulated the growth of a methanogen and uncovered a limited mechanistic link between the Monod equation and the methanogen’s metabolic network.