Open AccessTranscriptional Regulation and Functional Characterization of the Plasmid-Borne oqxAB Genes in Salmonella Typhimurium
Author(s) -
Bill Kwan-wai Chan,
Marcus Ho Yin Wong,
Edward Wai-Chi Chan,
Sheng Chen
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.02170-21
Subject(s) - plasmid , gene , microbiology and biotechnology , salmonella , ciprofloxacin , locus (genetics) , klebsiella pneumoniae , biology , escherichia coli , genetics , bacteria , antibiotics
The transferable mechanisms of quinolone resistance (TMQR) gene,oqxAB , has been widely detected inSalmonella and is commonly associated withaac(6′)-Ib-cr . It is thought to be associated with fluoroquinolone resistance, while its ancestor gene fromK. pneumoniae is not. This study evaluated the actual role of the plasmid-borneoqxAB genes inSalmonella and showed that it was not able to mediate intermediated resistance to fluoroquinolone and only did so when it coexisted withaac(6′)-Ib-cr .