Transcriptional Regulation and Functional Characterization of the Plasmid-Borne oqxAB Genes in Salmonella Typhimurium | Zendy

Bill Chan | Zendy; Marcus Ho Yin Wong | Zendy; Edward WaiChi Chan | Zendy; Sheng Chen | Zendy

Open Access

Transcriptional Regulation and Functional Characterization of the Plasmid-Borne oqxAB Genes in Salmonella Typhimurium

Author(s) -

Bill Chan,

Marcus Ho Yin Wong,

Edward WaiChi Chan,

Sheng Chen

Publication year - 2022

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.502

H-Index - 51

ISSN - 2165-0497

DOI - 10.1128/spectrum.02170-21

Subject(s) - plasmid , salmonella , gene , biology , genetics , microbiology and biotechnology , bacteria

The transferable mechanisms of quinolone resistance (TMQR) gene,oqxAB , has been widely detected inSalmonella and is commonly associated withaac(6′)-Ib-cr . It is thought to be associated with fluoroquinolone resistance, while its ancestor gene fromK. pneumoniae is not. This study evaluated the actual role of the plasmid-borneoqxAB genes inSalmonella and showed that it was not able to mediate intermediated resistance to fluoroquinolone and only did so when it coexisted withaac(6′)-Ib-cr .

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