Open AccessHopE and HopD Porin-Mediated Drug Influx Contributes to Intrinsic Antimicrobial Susceptibility and Inhibits Streptomycin Resistance Acquisition by Natural Transformation in Helicobacter pylori
Author(s) -
Yixin Liu,
Feng Yang,
Su Wang,
Wenjing Chi,
Li Ding,
Tao Liu,
Feng Zhu,
Danian Ji,
Jun Zhou,
Yi Fang,
Jinghao Zhang,
Ping Xiang,
Yanmei Zhang,
Hu Zhao
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01987-21
Subject(s) - porin , helicobacter pylori , transformation (genetics) , streptomycin , antimicrobial , drug resistance , microbiology and biotechnology , biology , bacterial outer membrane , genetics , escherichia coli , antibiotics , gene
Helicobacter pylori is constitutively competent for natural transformation (NT) and possesses an efficient system for homologous recombination, which could be utilized to study the NT-mediated horizontal gene transfer induced antibiotic resistance acquisition. Bacterial porins have drawn renewed attention because of their crucial role in antibiotic susceptibility.