Open AccessIn Vitro Antifungal Activity of Manogepix and Other Antifungal Agents against South African Candida auris Isolates from Bloodstream Infections
Author(s) -
Tsidiso G. Maphanga,
Ruth Mpembe,
Serisha D. Naicker,
Nelesh P. Govender,
AUTHOR_ID
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01717-21
Subject(s) - candida auris , antifungal , microbiology and biotechnology , bloodstream infection , fluconazole , biology , in vitro , echinocandins , medicine , caspofungin , genetics
SinceC. auris was first detected in South Africa in 2009, health care-associated transmission events and large outbreaks have led to this pathogen accounting for more than 1 in 10 cases of candidemia. A large proportion of South AfricanC. auris isolates are highly resistant to fluconazole but variably resistant to amphotericin B and echinocandins.