Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice | Zendy

Shigeyuki Tamiya | Zendy; Eisuke Yoshikawa | Zendy; Monami Ogura | Zendy; Etsushi Kuroda | Zendy; Koichiro Suzuki | Zendy; Yasuo Yoshioka | Zendy

Open Access

Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice

Author(s) -

Shigeyuki Tamiya,

Eisuke Yoshikawa,

Monami Ogura,

Etsushi Kuroda,

Koichiro Suzuki,

Yasuo Yoshioka

Publication year - 2021

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

ISSN - 2165-0497

DOI - 10.1128/spectrum.01588-21

Subject(s) - tlr2 , infiltration (hvac) , bronchoalveolar lavage , immunology , lung , mycoplasma pneumoniae , chemokine , inflammation , interleukin 8 , medicine , pneumonia , biology , tlr4 , physics , thermodynamics

Although Mp-induced pneumonia is usually a self-limiting disease, refractory life-threatening pneumonia is often induced. In addition, the development of alternative therapeutic strategies for Mp is expected because of the emergence of antibiotic-resistant Mp.

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