Open AccessNeutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice
Author(s) -
Shigeyuki Tamiya,
Eisuke Yoshikawa,
Monami Ogura,
Etsushi Kuroda,
Koichiro Suzuki,
Yasuo Yoshioka
Publication year - 2021
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
ISSN - 2165-0497
DOI - 10.1128/spectrum.01588-21
Subject(s) - tlr2 , infiltration (hvac) , bronchoalveolar lavage , immunology , lung , mycoplasma pneumoniae , chemokine , inflammation , interleukin 8 , medicine , pneumonia , biology , tlr4 , physics , thermodynamics
Although Mp-induced pneumonia is usually a self-limiting disease, refractory life-threatening pneumonia is often induced. In addition, the development of alternative therapeutic strategies for Mp is expected because of the emergence of antibiotic-resistant Mp.