Open AccessBismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria
Author(s) -
Tian Deng,
Yuqian Jia,
Ziwen Tong,
Jingru Shi,
Zhiqiang Wang,
Yuan Lv
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01578-21
Subject(s) - tigecycline , antibiotics , antimicrobial , microbiology and biotechnology , efflux , bacteria , antibiotic resistance , multiple drug resistance , biology , drug resistance , pharmacology , chemistry , biochemistry , genetics
Recently, high-level tigecycline resistance mediated bytet (X4) and its variants represents a serious challenge for global public health. Antibiotic adjuvant strategy that enhances the activity of the existing antibiotics by using nonantibiotic drugs offers a distinct approach to combat the antibiotic resistance crisis. In this study, we found that bismuth drugs involve bismuth nitrate, a compound previously approved for treatment of stomach-associated diseases, remarkably potentiates tigecycline activity againsttet (X)-positive bacteria.