Open AccessMultiple Routes of Antibody-Dependent Enhancement of SARS-CoV-2 Infection
Author(s) -
Kosuke Okuya,
Takanari Hattori,
Takeshi Saito,
Yoshihiro Takadate,
Michihito Sasaki,
Wakako Furuyama,
Andrea Marzi,
Yoichi Ohiro,
Satoshi Konno,
Takeshi Hattori,
Ayato Takada
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01553-21
Subject(s) - antibody , immunology , covid-19 , antibody dependent enhancement , receptor , neutralizing antibody , virology , coronavirus , severe acute respiratory syndrome coronavirus , medicine , respiratory system , biology , virus , disease , infectious disease (medical specialty) , dengue virus
Potential risks of antibody-dependent enhancement (ADE) in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been discussed and the proposed mechanism mostly depends on the Fc gamma receptor (FcγR). However, since FcγRs are exclusively expressed on immune cells, which are not primary targets of SARS-CoV-2, the clinical importance of ADE of SARS-CoV-2 infection remains controversial.