Open AccessComparable Effectiveness of Cefuroxime and Piperacillin-Tazobactam as Empirical Therapy for Methicillin-Susceptible Staphylococcus aureus Bacteremia
Author(s) -
Robert Strengen Bigseth,
Håkon Sandholdt,
Andreas Petersen,
Christian Østergaard,
Thomas Benfield,
Louise Thorlacius-Ussing
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01530-21
Subject(s) - medicine , cefuroxime , piperacillin/tazobactam , hazard ratio , bacteremia , propensity score matching , confidence interval , methicillin resistant staphylococcus aureus , tazobactam , retrospective cohort study , proportional hazards model , antibacterial agent , surgery , piperacillin , staphylococcus aureus , antibiotics , microbiology and biotechnology , antibiotic resistance , genetics , bacteria , pseudomonas aeruginosa , biology , imipenem
This multicenter retrospective matched cohort study evaluated the effect of empirical antimicrobial therapy on the clinical outcome of methicillin-susceptibleStaphylococcus aureus bacteremia (MS-SAB) in >1100 adult patients. To the best of our knowledge, this is the largest study to date evaluating the effect of empirical treatment on the MS-SAB outcome.