DsrA Modulates Central Carbon Metabolism and Redox Balance by Directly Repressing pflB Expression in Salmonella Typhimurium | Zendy

Rui Dong | Zendy; Yuan Liang | Zendy; Shoukui He | Zendy; Yan Cui | Zendy; Chunlei Shi | Zendy; Yiping He | Zendy; Xianming Shi | Zendy

Open Access

DsrA Modulates Central Carbon Metabolism and Redox Balance by Directly Repressing pflB Expression in Salmonella Typhimurium

Author(s) -

Rui Dong,

Yuan Liang,

Shoukui He,

Yan Cui,

Chunlei Shi,

Yiping He,

Xianming Shi

Publication year - 2022

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

ISSN - 2165-0497

DOI - 10.1128/spectrum.01522-21

Subject(s) - biology , rnase p , gene expression , genetics , gene , biochemistry , microbiology and biotechnology , rna

Small RNA DsrA plays an important role in defending against oxidative stress in bacteria. In this study, we identified a novel target (pflB , encoding pyruvate-formate lyase) of DsrA and demonstrated its potential regulatory mechanism inS. Typhimurium by transcriptome analysis.In silico prediction revealed a direct base pairing between DsrA andpflB mRNA, which was confirmed in site-directed mutagenesis experiments.

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