Open AccessA Multiwell-Plate Caenorhabditis elegans Assay for Assessing the Therapeutic Potential of Bacteriophages against Clinical Pathogens
Author(s) -
Prasanth Manohar,
Sebastian Leptihn,
Namasivayam Elangovan,
Archana Loganathan,
Ramesh Nachimuthu,
Sebastian Leptihn
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01393-21
Subject(s) - lytic cycle , biology , phage therapy , bacteriophage , klebsiella pneumoniae , caenorhabditis elegans , enterobacter cloacae , microbiology and biotechnology , virulence , bacteria , model organism , lysogenic cycle , escherichia coli , computational biology , virology , virus , genetics , gene
Validating the efficacy and safety of phages prior to clinical application is crucial to see phage therapy in practice. Current animal models include mice and insect larvae, which pose ethical or technical challenges.