Open AccessThe Interferon-Inducible Human PLSCR1 Protein Is a Restriction Factor of Human Cytomegalovirus
Author(s) -
Hidetaka Sadanari,
Masaya Takemoto,
Tomoki Ishida,
Hikaru Otagiri,
Tohru Daikoku,
Tsugiya Murayama,
Shuichi Kusano
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.01342-21
Subject(s) - human cytomegalovirus , biology , creb , viral replication , transactivation , microbiology and biotechnology , virology , gene expression , transcription factor , gene , virus , genetics
Because several IFN-stimulated genes (ISGs) have been reported to suppress HCMV replication, HCMV replication is thought to be regulated by an IFN-mediated host defense mechanism, but the mechanism remains unclear. PLSCR1 expression is induced in response to viral infection and IFN treatment, and PLSCR1 has been reported to play an important role in IFN-dependent antiviral responses.