Open AccessSub-Inhibitory Concentrations of Oxacillin, but Not Clindamycin, Linezolid, or Tigecycline, Decrease Staphylococcal Phenol-Soluble Modulin Expression in Community-Acquired Methicillin-Resistant Staphylococcus aureus
Author(s) -
Elisabeth Hodille,
Laetitia Béraud,
Séverine Périan,
Valentine Berti,
Michèle Bes,
Anne Tristan,
Emilie Blond,
Gérard Lina,
Oana Dumitrescu
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00808-21
Subject(s) - linezolid , microbiology and biotechnology , clindamycin , tigecycline , antibiotics , staphylococcus aureus , toxin , biology , chemistry , vancomycin , bacteria , genetics
Staphylococcal toxins play an important role in the physiopathology of staphylococcal infections. Subinhibitory concentrations (sub-MIC) of antibiotics modulatein vitro toxins expression inS. aureus : clindamycin (CLI) and linezolid (LIN) display an anti-toxin effect on Panton-Valentine leucocidin and alpha-hemolysin production, while oxacillin (OXA) has an inducing effect.