Tissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum | Zendy

Sarah Forrester | Zendy; Amy Goundry | Zendy; Bruna Torres Dias | Zendy; Thyago Leal-Calvo | Zendy; Milton Ozório Moraes | Zendy; Paul M. Kaye | Zendy; Jeremy C. Mottram | Zendy; Ana Paula C. A. Lima | Zendy

Open Access

Tissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum

Author(s) -

Sarah Forrester,

Amy Goundry,

Bruna Torres Dias,

Thyago Leal-Calvo,

Milton Ozório Moraes,

Paul M. Kaye,

Jeremy C. Mottram,

Ana Paula C. A. Lima

Publication year - 2022

Publication title -

microbiology spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.502

H-Index - 51

ISSN - 2165-0497

DOI - 10.1128/spectrum.00679-22

Subject(s) - visceral leishmaniasis , leishmania infantum , leishmania donovani , parasite hosting , leishmania , leishmaniasis , biology , virology , host (biology) , amastigote , immunology , genetics , world wide web , computer science

Visceral leishmaniasis (VL) is caused by two species ofLeishmania parasites,L. donovani in the Old World andL. infantum in the New World and countries bordering the Mediterranean. Although cardinal features such as hepato-splenomegaly and alterations in blood and immune function are evident, clinical presentation may vary by geography, with for example severe bleeding often associated with VL in Brazil.

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