Open AccessTissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum
Author(s) -
Sarah Forrester,
Amy Goundry,
Bruna T. Dias,
Thyago Leal-Calvo,
Milton Ozório Moraes,
Paul M. Kaye,
Jeremy C. Mottram,
Ana Paula Lima
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00679-22
Subject(s) - visceral leishmaniasis , leishmania infantum , leishmania donovani , leishmaniasis , leishmania , biology , parasite hosting , immunology , immune system , virology , world wide web , computer science
Visceral leishmaniasis (VL) is caused by two species ofLeishmania parasites,L. donovani in the Old World andL. infantum in the New World and countries bordering the Mediterranean. Although cardinal features such as hepato-splenomegaly and alterations in blood and immune function are evident, clinical presentation may vary by geography, with for example severe bleeding often associated with VL in Brazil.