Open AccessRelationship between DNA Methylation Profiles and Active Tuberculosis Development from Latent Infection: a Pilot Study in Nested Case-Control Design
Author(s) -
Ying Du,
Xu Gao,
Jiaoxia Yan,
Haoran Zhang,
Xuefang Cao,
Boxuan Feng,
Yijun He,
Yongpeng He,
Tonglei Guo,
Henan Xin,
Lei Gao
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00586-22
Subject(s) - tuberculosis , latent tuberculosis , mycobacterium tuberculosis , active tuberculosis , nested case control study , population , disease , dna methylation , quarter (canadian coin) , immunology , medicine , biology , environmental health , case control study , genetics , geography , gene , pathology , gene expression , archaeology
Approximately a quarter of the world population had been infected withMycobacterium tuberculosis , and about 5 to 10% of these individuals might develop active disease in their lifetimes. As a critical component of the “end TB strategies,” preventive treatment was shown to protect 60 to 90% of high-risk LTBIs from developing active disease.