Open AccessEradication of Biofilm-Mediated Methicillin-Resistant Staphylococcus aureus Infections In Vitro : Bacteriophage-Antibiotic Combination
Author(s) -
Razieh Kebriaei,
Katherine L. Lev,
Rahi M. Shah,
Kyle Stamper,
Dana Holger,
Taylor Morrisette,
Ashlan J Kunz Coyne,
Susan M. Lehman,
Michael J. Rybak
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00411-22
Subject(s) - biofilm , antibiotics , microbiology and biotechnology , staphylococcus aureus , bacteriophage , antibiotic resistance , multiple drug resistance , biology , methicillin resistant staphylococcus aureus , bacteria , escherichia coli , genetics , gene
Biofilm-associated multidrug-resistant infections pose significant challenges for antibiotic therapy. The extracellular polymeric matrix of biofilms presents an impediment for antibiotic diffusion, facilitating the emergence of multidrug-resistant populations.