Open AccessDevelopment of a Machine Learning-Based Cysticidal Assay and Identification of an Amebicidal and Cysticidal Marine Microbial Metabolite against Acanthamoeba
Author(s) -
Brian Shing,
Mina Balen,
William Fenical,
Anjan Debnath
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
ISSN - 2165-0497
DOI - 10.1128/spectrum.00077-22
Subject(s) - acanthamoeba , acanthamoeba keratitis , blinding , identification (biology) , microbiology and biotechnology , metabolite , keratitis , medicine , biology , medline , dermatology , ecology , biochemistry
The free-livingAcanthamoeba can exist as a trophozoite or cyst and both stages can cause painful blinding keratitis. Infection recurrence occurs in approximately 10% of cases due to the lack of efficient drugs that can kill both trophozoites and cysts.