Open AccessRetrospective Evaluation of Various Serological Assays and Multiple Parameters for Optimal Diagnosis of Lyme Neuroborreliosis in a Routine Clinical Setting
Author(s) -
Tamara van Gorkom,
W. Voet,
Gijs H J van Arkel,
Michiel Heron,
B. J. A. Hoeve-Bakker,
Daan W. Notermans,
Steven Thijsen,
Kristin Kremer
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00061-22
Subject(s) - neuroborreliosis , lyme neuroborreliosis , serology , lyme disease , medicine , retrospective cohort study , borrelia , borrelia burgdorferi , virology , immunology , pathology , antibody
The diagnosis of LNB is established by clinical symptoms, pleocytosis, and proof of intrathecal synthesis ofBorrelia -specific antibodies. Laboratory diagnosis of LNB is challenging, and validated diagnostic algorithms are lacking.