Open AccessGut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome
Author(s) -
Yanan Hao,
Yanni Feng,
Xiaowei Yan,
Liang Chen,
Xiangping Ma,
Xiangfang Tang,
Ruqing Zhong,
Zhongyi Sun,
Manjree Agarwal,
Hongfu Zhang,
Yong Zhao
Publication year - 2022
Publication title -
microbiology spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.502
H-Index - 51
ISSN - 2165-0497
DOI - 10.1128/spectrum.00028-22
Subject(s) - metabolome , gut flora , biology , semen quality , semen , sperm , male infertility , andrology , medicine , infertility , semen analysis , docosahexaenoic acid , endocrinology , physiology , polyunsaturated fatty acid , fatty acid , pregnancy , immunology , metabolite , biochemistry , genetics
HFD decreases male fertility via upsetting gut microbiota and transplantation of AOS-benefited gut microbiota (A10-FMT) improves gut microbiota to ameliorate HFD-reduced male fertility. Moreover, A10-FMT improved liver function to benefit the blood metabolome and simultaneously ameliorated the testicular microenvironment to turn the spermatogenesis process on.