Open AccessBile Acids, Gut Microbes, and the Neighborhood Food Environment—a Potential Driver of Colorectal Cancer Health Disparities
Author(s) -
Patricia G. Wolf,
Doratha A Byrd,
Kate Cares,
Hanchu Dai,
Angela Odoms-Young,
H. Rex Gaskins,
Jason M. Ridlon,
Lisa TussingHumphreys
Publication year - 2022
Publication title -
msystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.931
H-Index - 39
ISSN - 2379-5077
DOI - 10.1128/msystems.01174-21
Subject(s) - colorectal cancer , cancer , digestion (alchemy) , nutrient , medicine , chemistry , cancer research , biochemistry , biology , ecology , chromatography
Bile acids (BAs) facilitate nutrient digestion and absorption and act as signaling molecules in a number of metabolic and inflammatory pathways. Expansion of the BA pool and increased exposure to microbial BA metabolites has been associated with increased colorectal cancer (CRC) risk.