Open AccessThe Gut Microbial Diversity of Newly Diagnosed Diabetics but Not of Prediabetics Is Significantly Different from That of Healthy Nondiabetics
Author(s) -
Akshay H. Gaike,
Dhiraj Paul,
Shrikant Bhute,
Dhiraj Dhotre,
Pranav Pande,
Smitha Upadhyaya,
Yugandhar B. S. Reddy,
Ramya Sampath,
Debjani Ghosh,
D. Chandraprabha,
Jhankar Acharya,
Gautam Banerjee,
Vilas P. Sinkar,
Surendra Ghaskadbi,
Yogesh S. Shouche
Publication year - 2020
Publication title -
msystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.931
H-Index - 39
ISSN - 2379-5077
DOI - 10.1128/msystems.00578-19
Subject(s) - akkermansia , ruminococcus , gut flora , medicine , diabetes mellitus , biology , type 2 diabetes , endocrinology , physiology , lactobacillus , biochemistry , fermentation
Gut microbiota is considered to play a role in disease progression, and previous studies have reported an association of microbiome dysbiosis with T2D. In this study, we have attempted to investigate gut microbiota of ND, PreDMs, NewDMs, and KnownDMs. We found that the genera Akkermansia and Blautia decreased significantly ( P < 0.05) in treatment-naive diabetics and were restored in KnownDMs on antidiabetic treatment. To the best of our knowledge, comparative studies on shifts in the microbial community in individuals of different diabetic states are lacking. Understanding the transition of microbiota and its association with serum biomarkers in diabetics with different disease states may pave the way for new therapeutic approaches for T2D.