Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils | Zendy

Natalia Małachowa | Zendy; Brett A. Freedman | Zendy; Daniel E. Sturdevant | Zendy; Scott D. Kobayashi | Zendy; Vinod Nair | Zendy; Friederike Feldmann | Zendy; Tregei Starr | Zendy; Olivia SteeleMortimer | Zendy; John C. Kash | Zendy; Jeffery K. Taubenberger | Zendy; Heinz Feldmann | Zendy; Frank R. DeLeo | Zendy

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Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils

Author(s) -

Natalia Małachowa,

Brett A. Freedman,

Daniel E. Sturdevant,

Scott D. Kobayashi,

Vinod Nair,

Friederike Feldmann,

Tregei Starr,

Olivia SteeleMortimer,

John C. Kash,

Jeffery K. Taubenberger,

Heinz Feldmann,

Frank R. DeLeo

Publication year - 2018

Publication title -

msphere

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.749

H-Index - 39

ISSN - 2379-5042

DOI - 10.1128/mspheredirect.00567-17

Subject(s) - pandemic , influenza a virus , staphylococcus aureus , biology , microbiology and biotechnology , human influenza , immunology , h1n1 influenza , function (biology) , virology , virus , covid-19 , bacteria , medicine , infectious disease (medical specialty) , disease , genetics , pathology

A long-standing notion is that IAV inhibits normal neutrophil function and thereby predisposes individuals to secondary bacterial infections. Here we report that seasonal H1N1 IAV primes human neutrophils for enhanced killing ofStaphylococcus aureus . Moreover, we provide a comprehensive view of the changes in neutrophil gene expression during interaction with seasonal or pandemic IAV and report how these changes relate to functions such as bactericidal activity. This study expands our knowledge of IAV interactions with human neutrophils.

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